No. 8 USC will be looking to extend its winning streak to four games when it travels to Boulder to face Colorado on Saturday. The Trojans are 21.5-point favorites in the latest USC vs. Colorado odds via SportsLine consensus, while the over/under for total points scored is 73.
Colorado vs. USC odds, spread, line
- Spread: USC -21.5
- Over/under: 73 points
- Money line: USC -1590, Colorado +873
Colorado vs. USC picks
SportsLine's proven computer model simulates every FBS college football game 10,000 times. The model is leaning Under on the point total, projecting the teams to combine for 68 points. The model also says one side of the spread hits in well over 50% of simulations. You can see the model's picks at SportsLine.
Deion Sanders predictions
Colorado head coach Deion Sanders is known for his bold predictions, and he's not backing down from USC this week.
"We're going to beat USC," Sanders said on Monday. "I don't care what anybody says. We're going to beat USC."
Sanders' confidence is understandable. The Buffaloes have been one of the most surprising teams in the Pac-12 this season, entering the game with a 3-1 record. Colorado's only loss came last week against Oregon, but the Buffaloes were competitive in that game, trailing by just two touchdowns at halftime.
USC vs. Colorado prediction
The Trojans are the more talented team on paper, but the Buffaloes have a lot of momentum and they're playing at home. I'm going to take Colorado to cover the spread in this one.
Pick: Colorado +21.5
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